گردهمایی علمی انجمن


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17159

The Impacts of Gastroileostomy Rat Model on Glucagon-like Peptide-1
a Promising Model to Control Type 2 Diabetes Mellitus

Abstract
Background One of the new current treatment options for Diabetes Mellitus is about increasing glucagon-like peptide-1 (GLP-1)
activity. GLP-1 with its incretin effect showed major role in glucose homeostasis. Gastroileostomy can increase GLP-1 secretion
by rapid delivery of undigested food to the terminal ileum. We studied the early effects of a gastroileostomy on serum levels of
GLP-1, glucose, and insulin in rats.
Methods Gastroileostomies with side-to-side anastomosis were performed on 15 male New Zealand rats. Blood samples were
obtained before and 1 week after the gastroileostomy.
Results Our results showed that the rats lost a lot of weight from start (330 ± 15 g) to the end (240 ± 25 g) of the experiment (p =
0.048). The data analysis showed that the gastroileostomy surgery elevates the level of GLP-1in plasma significantly (89.1852 vs.
177.440 respectively; p < 0.001) and caused a significant decrease in plasma glucose as well (92.00 and 66.29 mg/dL respectively;
p < 0.001). However, the insulin state elevated after the surgery significantly (8.03 vs. 9.89; p < 0.001).
Conclusion In this study, we showed the effectiveness of gastroileostomy treatment to decrease body weight and plasma glucose
with increased GLP-1 in rats. This small rat model suggests the potential of this surgery to treat type 2 diabetes mellitus.
Keywords Glucagon-like peptide . Gastroileostomy . Diabetes mellitus . Incretin . Glucose

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